2024 Publications
Clinically relevant molecular hallmarks of PFA ependymomas display intratumoral heterogeneity and correlate with tumor morphology
Gödicke, S., Kresbach, C., Ehlert, M., Obrecht, D., Altendorf, L., Hack, K., von Hoff, K., Carén, H., Melcher, V., Kerl, K., Englinger, B., Filbin, M., Pajtler, K. W., Gojo, J., Pietsch, T., Rutkowski, S., & Schüller, U.
ACTA NEUROPATHOLOGICA - 2023
https://doi.org/10.1007/s00401-023-02682-x
ACTA NEUROPATHOLOGICA - 2023
https://doi.org/10.1007/s00401-023-02682-x
An ERK5-PFKFB3 axis regulates glycolysis and represents a therapeutic vulnerability in pediatric diffuse midline glioma
Casillo, S. M., Gatesman, T. A., Chilukuri, A., Varadharajan, S., Johnson, B. J., David Premkumar, D. R., Jane, E. P., Plute, T. J., Koncar, R. F., Stanton, A. J., Biagi-Junior, C. A. O., Barber, C. S., Halbert, M. E., Golbourn, B. J., Halligan, K., Cruz, A. F., Mansi, N. M., Cheney, A., Mullett, S. J., Land, C. V., … Filbin, M. G., ... Agnihotri, S.
CELL REPORTS - 2024
https://doi.org/10.1016/j.celrep.2023.113557
CELL REPORTS - 2024
https://doi.org/10.1016/j.celrep.2023.113557
A road map for the treatment of pediatric diffuse midline glioma
Koschmann, C., Al-Holou, W. N., Alonso, M. M., Anastas, J., Bandopadhayay, P., Barron, T., Becher, O., Cartaxo, R., Castro, M. G., Chung, C., Clausen, M., Dang, D., Doherty, R., Duchatel, R., Dun, M., Filbin, M., Franson, A., Galban, S., Garcia Moure, M., Garton, H., … Venneti, S.
CANCER CELL - 2024
https://doi.org/10.1016/j.ccell.2023.11.002
CANCER CELL - 2024
https://doi.org/10.1016/j.ccell.2023.11.002
2023 Publications
TIM-3 blockade in diffuse intrinsic pontine glioma models promotes tumor regression and antitumor immune memory 4
Ausejo-Mauleon, I., Labiano, S., de la Nava, D., Laspidea, V., Zalacain, M., Marrodán, L., García-Moure, M., González-Huarriz, M., Hervás-Corpión, I., Dhandapani, L., Vicent, S., Collantes, M., Peñuelas, I., Becher, O. J., Filbin, M. G., Jiang, L., Labelle, J., de Biagi-Junior, C. A. O., Nazarian, J., Laternser, S., … Alonso, M. M.
CANCER CELL - 2023
https://doi.org/10.1016/j.ccell.2023.09.001
CANCER CELL - 2023
https://doi.org/10.1016/j.ccell.2023.09.001
Diffuse Midline Glioma Invasion and Metastasis Rely on Cell-autonomous Signaling
Bruschi, M., Midjek, L., Ajlil, Y., Vairy, S., Lancien, M., Ghermaoui, S., Kergrohen, T., Verreault, M., Idbaih, A., de Biagi, C. A. O., Jr, Liu, I., Filbin, M. G., Beccaria, K., Blauwblomme, T., Puget, S., Tauziede-Espariat, A., Varlet, P., Dangouloff-Ros, V., Boddaert, N., Le Teuff, G., … Castel, D.
NEURO-ONCOLOGY - 2023
https://doi.org/10.1093/neuonc/noad161
NEURO-ONCOLOGY - 2023
https://doi.org/10.1093/neuonc/noad161
A comprehensive genomic study of 390 H3F3A-mutant pediatric and adult diffuse high-grade gliomas, CNS WHO grade 4
Williams, E. A., Brastianos, P. K., Wakimoto, H., Zolal, A., Filbin, M. G., Cahill, D. P., Santagata, S., & Juratli, T. A.
ACTA NEUROPATHOLOGICA - 2023
https://doi.org/10.1007/s00401-023-02609-6
ACTA NEUROPATHOLOGICA - 2023
https://doi.org/10.1007/s00401-023-02609-6
Clinical efficacy of ONC201 in H3K27M-mutant diffuse midline gliomas is driven by disruption of integrated metabolic and epigenetic pathways
Venneti, S., Kawakibi, A. R., Ji, S., Waszak, S. M., Sweha, S. R., Mota, M., Pun, M., Deogharkar, A., Chung, C., Tarapore, R. S., Ramage, S., Chi, A., Wen, P. Y., Arrillaga-Romany, I., Batchelor, T. T., Butowski, N. A., Sumrall, A., Shonka, N., Harrison, R. A., de Groot, J., … Filbin, M. G., ... Koschmann, C.
CANCER DISCOVERY - 2023
https://doi.org/10.1158/2159-8290.CD-23-0131
CANCER DISCOVERY - 2023
https://doi.org/10.1158/2159-8290.CD-23-0131
Mapping pediatric brain tumors to their origins in the developing cerebellum
Okonechnikov, K., Joshi, P., Sepp, M., Leiss, K., Sarropoulos, I., Murat, F., Sill, M., Beck, P., Chan, K. C., Korshunov, A., Sahm, F., Deng, M. Y., Sturm, D., DeSisto, J., Donson, A. M., Foreman, N. K., Green, A. L., Robinson, G., Orr, B. A., Gao, Q., … Filbin, M. G., ... Pfister, S. M.
NEURO-ONCOLOGY - 2023
https://doi.org/10.1093/neuonc/noad124
NEURO-ONCOLOGY - 2023
https://doi.org/10.1093/neuonc/noad124
Why haven't we solved intracranial pediatric ependymoma? Current questions and barriers to treatment advances
Hwang, E. I., Hanson, D., Filbin, M. G., & Mack, S. C.
NEUOPLASIA - 2023
https://doi.org/10.1016/j.neo.2023.100895
NEUOPLASIA - 2023
https://doi.org/10.1016/j.neo.2023.100895
Common molecular features of H3K27M DMGs and PFA ependymomas map to hindbrain developmental pathways
Pun, M., Pratt, D., Nano, P. R., Joshi, P. K., Jiang, L., Englinger, B., Rao, A., Cieslik, M., Chinnaiyan, A. M., Aldape, K., Pfister, S., Filbin, M. G., Bhaduri, A., & Venneti, S.
ACTA NEUROPATHOLOGICA COMMUNICATIONS - 2023
https://doi.org/10.1186/s40478-023-01514-z
ACTA NEUROPATHOLOGICA COMMUNICATIONS - 2023
https://doi.org/10.1186/s40478-023-01514-z
Neuronal-Activity dependent mechanismas of small cell lung cancer progression
Savchuk, S., Gentry, K., Wang, W., Carleton, E., Yalçın, B., Liu, Y., Pavarino, E. C., LaBelle, J., Toland, A. M., Woo, P. J., Qu, F., Filbin, M. G., Krasnow, M. A., Sabatini, B. L., Sage, J., Monje, M., & Venkatesh, H. S.
BIORXIV - 2023
https://doi.org/10.1101/2023.01.19.524430
BIORXIV - 2023
https://doi.org/10.1101/2023.01.19.524430
2022 Publications
The landscape of tumor cell states and spatial organization in H3-K27M mutant diffuse midline glioma across age and location
Liu, I., Jiang, L., Samuelsson, E. R., Marco Salas, S., Beck, A., Hack, O. A., Jeong, D., Shaw, M. L., Englinger, B., LaBelle, J., Mire, H. M., Madlener, S., Mayr, L., Quezada, M. A., Trissal, M., Panditharatna, E., Ernst, K. J., Vogelzang, J., Gatesman, T. A., Halbert, M. E., … Filbin, M. G.
NATURE GENETICS - 2022
https://doi.org/10.1038/s41588-022-01236-3
NATURE GENETICS - 2022
https://doi.org/10.1038/s41588-022-01236-3
Characterizing the biology of primary brain tumors and their microenvironment via single-cell profiling methods
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Gonzalez Castro, L. N., Liu, I., & Filbin, M.
NEURO-ONCOLOGY - 2022 https://doi.org/10.1093/neuonc/noac211 |
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BAF complex maintains glioma stem cells in pediatric H3K27M-glioma
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Panditharatna, E., G Marques, J., Wang, T., Trissal, M. C., Liu, I., Jiang, L., Beck, A., Groves, A., Dharia, N. V., Li, D., Hoffman, S. E., Kugener, G., Shaw, M. L., Mire, H. M., Hack, O. A., Dempster, J. M., Lareau, C., Dai, L., Sigua, L. H., Quezada, M. A., … Filbin, M. G.
CANCER DISCOVERY - 2022 https://doi.org/10.1158/2159-8290.CD-21-1491 |
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VRK1 as a synthetic lethal target in VRK2 promoter-methylated cancers of the nervous system
So, J., Mabe, N. W., Englinger, B., Chow, K. H., Moyer, S. M., Yerrum, S., Trissal, M. C., Marques, J. G., Kwon, J. J., Shim, B., Pal, S., Panditharatna, E., Quinn, T., Schaefer, D. A., Jeong, D., Mayhew, D. L., Hwang, J., Beroukhim, R., Ligon, K. L., Stegmaier, K., … Filbin G. M., Hahn, W. C.
JCI INSIGHT - 2022
https://doi.org/10.1172/jci.insight.158755
JCI INSIGHT - 2022
https://doi.org/10.1172/jci.insight.158755
Immunotherapy approaches for the treatment of diffuse midline gliomas
Bernstock, J. D., Hoffman, S. E., Kappel, A. D., Valdes, P. A., Essayed, W., Klinger, N. V., Kang, K. D., Totsch, S. K., Olsen, H. E., Schlappi, C. W., Filipski, K., Gessler, F. A., Baird, L., Filbin, M. G., Hashizume, R., Becher, O. J., & Friedman, G. K.
ONCOIMMUNOLOGY - 2022
https://doi.org/10.1080/2162402X.2022.2124058
ONCOIMMUNOLOGY - 2022
https://doi.org/10.1080/2162402X.2022.2124058
A druggable addiction to de novo pyrimidine biosynthesis in diffuse midline glioma
Pal, S., Kaplan, J. P., Nguyen, H., Stopka, S. A., Savani, M. R., Regan, M. S., Nguyen, Q. D., Jones, K. L., Moreau, L. A., Peng, J., Dipiazza, M. G., Perciaccante, A. J., Zhu, X., Hunsel, B. R., Liu, K. X., Alexandrescu, S., Drissi, R., Filbin, M. G., McBrayer, S. K., Agar, N. Y. R., … Haas-Kogan, D. A.
CANCER CELL - 2022
https://doi.org/10.1016/j.ccell.2022.07.012
CANCER CELL - 2022
https://doi.org/10.1016/j.ccell.2022.07.012
An affinity for brainstem microglia in pediatric high-grade gliomas of brainstem origin
Zats, L. P., Ahmad, L., Casden, N., Lee, M. J., Belzer, V., Adato, O., Bar Cohen, S., Ko, S. B., Filbin, M. G., Unger, R., Lauffenburger, D. A., Segal, R. A., & Behar, O.
NEURO-ONCOLOGY ADVANCES - 2022
https://doi.org/10.1093/noajnl/vdac117
NEURO-ONCOLOGY ADVANCES - 2022
https://doi.org/10.1093/noajnl/vdac117
Single-cell epigenetic analysis reveals principles of chromatin states in H3.3-K27M gliomas
Harpaz, N., Mittelman, T., Beresh, O., Griess, O., Furth, N., Salame, T. M., Oren, R., Fellus-Alyagor, L., Harmelin, A., Alexandrescu, S., Marques, J. G., Filbin, M. G., Ron, G., & Shema, E.
MOLECULAR CELL - 2022
https://doi.org/10.1016/j.molcel.2022.05.023
MOLECULAR CELL - 2022
https://doi.org/10.1016/j.molcel.2022.05.023
Activation of Hedgehog signaling by the oncogenic RELA fusion reveals a primary cilia-dependent vulnerability in Supratentorial Ependymoma
de Almeida Magalhães, T., Alencastro Veiga Cruzeiro, G., Ribeiro de Sousa, G., Englinger, B., Fernando Peinado Nagano, L., Ancliffe, M., Rodrigues da Silva, K., Jiang, L., Gojo, J., Cherry Liu, Y., Carline, B., Kuchibhotla, M., Pinto Saggioro, F., Kazue Nagahashi Marie, S., Mieko Oba-Shinjo, S., Andres Yunes, J., Gomes de Paula Queiroz, R., Alberto Scrideli, C., Endersby, R., Filbin, M. G., … Valera, E. T.
NEURO-ONCOLOGY - 2022
https://doi.org/10.1093/neuonc/noac147
NEURO-ONCOLOGY - 2022
https://doi.org/10.1093/neuonc/noac147
Therapeutic targeting of prenatal pontine ID1 signaling in diffuse midline glioma
Messinger, D., Harris, M. K., Cummings, J. R., Thomas, C., Yang, T., Sweha, S. R., Woo, R., Siddaway, R., Burkert, M., Stallard, S., Qin, T., Mullan, B., Siada, R., Ravindran, R., Niculcea, M., Dowling, A. R., Bradin, J., Ginn, K. F., Gener, M. A. H., Dorris, K., … Filbin, M. G., ... Yadav, V. N.
NEURO-ONCOLOGY - 2022
https://doi.org/10.1093/neuonc/noac141
NEURO-ONCOLOGY - 2022
https://doi.org/10.1093/neuonc/noac141
Bromodomain and Extra-Terminal Protein Inhibitors: Biologic Insights and Therapeutic Potential in Pediatric Brain Tumors
Groves, A., Clymer, J., & Filbin, M. G.
PHARMACEUTICALS (BASEL, SWITZERLAND) - 2022
https://doi.org/10.3390/ph15060665
PHARMACEUTICALS (BASEL, SWITZERLAND) - 2022
https://doi.org/10.3390/ph15060665
GD2-CAR T cell therapy for H3K27M-mutated diffuse midline gliomas
Majzner, R. G., Ramakrishna, S., Yeom, K. W., Patel, S., Chinnasamy, H., Schultz, L. M., Richards, R. M., Jiang, L., Barsan, V., Mancusi, R., Geraghty, A. C., Good, Z., Mochizuki, A. Y., Gillespie, S. M., Toland, A. M. S., Mahdi, J., Reschke, A., Nie, E. H., Chau, I. J., Rotiroti, M. C., … Filbin, M. G., ... Monje, M.
NATURE - 2022
https://doi.org/10.1038/s41586-022-04489-4
NATURE - 2022
https://doi.org/10.1038/s41586-022-04489-4
Imipridones affect tumor bioenergetics and promote cell lineage differentiation in diffuse midline gliomas
Przystal, J. M., Cianciolo Cosentino, C., Yadavilli, S., Zhang, J., Laternser, S., Bonner, E. R., Prasad, R., Dawood, A. A., Lobeto, N., Chin Chong, W., Biery, M. C., Myers, C., Olson, J. M., Panditharatna, E., Kritzer, B., Mourabit, S., Vitanza, N. A., Filbin, M. G., de Iuliis, G. N., Dun, M. D., … Nazarian, J.
NEURO-ONCOLOGY - 2022
https://doi.org/10.1093/neuonc/noac041
NEURO-ONCOLOGY - 2022
https://doi.org/10.1093/neuonc/noac041
2021 Publications
The imitation game: How glioblastoma outmaneuvers immune attack
Understanding the epigenetic landscape and cellular architecture of childhood brain tumors
Alencastro Veiga Cruzeiro, G., Rota, C., Hack, O. A., Segal, R., & Filbin, M. G.
NEUROCHEMISTRY INTERNATIONAL - 2021
https://doi.org/10.1016/j.neuint.2020.104940
NEUROCHEMISTRY INTERNATIONAL - 2021
https://doi.org/10.1016/j.neuint.2020.104940
Outcomes after first relapse of childhood intracranial ependymoma
Tsai, J. W., Manoharan, N., Alexandrescu, S., Zimmerman, M. A., Scully, J., Chordas, C., Clymer, J., Wright, K. D., Filbin, M., Ullrich, N. J., Marcus, K. J., Haas-Kogan, D., Chi, S. N., Bandopadhayay, P., & Yeo, K. K.
PEDIATRIC BLOOD & CANCER - 2021
https://doi.org/10.1002/pbc.28930
PEDIATRIC BLOOD & CANCER - 2021
https://doi.org/10.1002/pbc.28930
Targeting fibroblast growth factor receptors to combat aggressive ependymoma.
Lötsch, D., Kirchhofer, D., Englinger, B., Jiang, L., Okonechnikov, K., Senfter, D., Laemmerer, A., Gabler, L., Pirker, C., Donson, A. M., Bannauer, P., Korbel, P., Jaunecker, C. N., Hübner, J. M., Mayr, L., Madlener, S., Schmook, M. T., Ricken, G., Maaß, K., Grusch, M., … Filbin, M. G., ... Gojo, J.
ACTA NEUROPATHOLOGICA- 2021
https://doi.org/10.1007/s00401-021-02327-x
ACTA NEUROPATHOLOGICA- 2021
https://doi.org/10.1007/s00401-021-02327-x
Targeting integrated epigenetic and metabolic pathways in lethal childhood PFA ependymomas
Panwalkar, P., Tamrazi, B., Dang, D., Chung, C., Sweha, S., Natarajan, S. K., Pun, M., Bayliss, J., Ogrodzinski, M. P., Pratt, D., Mullan, B., Hawes, D., Yang, F., Lu, C., Sabari, B. R., Achreja, A., Heon, J., Animasahun, O., Cieslik, M., Dunham, C., … Filbin, M. G., ... Venneti, S.
SCIENCE TRANSLATIONAL MEDICINE - 2021
https://doi.org/10.1126/scitranslmed.abc0497
SCIENCE TRANSLATIONAL MEDICINE - 2021
https://doi.org/10.1126/scitranslmed.abc0497
2020 Publications
Into Thin Air: Hypoxia drives metabolic and epigenomic deregulation of lethal pediatric ependymoma
Englinger, B., Hack, O. A., & Filbin, M. G.
DEVELOPMENTAL CELL - 2020
https://doi.org/10.1016/j.devcel.2020.06.020
DEVELOPMENTAL CELL - 2020
https://doi.org/10.1016/j.devcel.2020.06.020
Molecular and clinicopathologic features of gliomas harboring NTRK fusions
Torre, M., Vasudevaraja, V., Serrano, J., DeLorenzo, M., Malinowski, S., Blandin, A. F., Pages, M., Ligon, A. H., Dong, F., Meredith, D. M., Nasrallah, M. P., Horbinski, C., Dahiya, S., Ligon, K. L., Santi, M., Ramkissoon, S. H., Filbin, M. G., Snuderl, M., & Alexandrescu, S.
ACTA NEUROPATHOLOGICA COMMUNICATIONS - 2020
https://doi.org/10.1186/s40478-020-00980-z
ACTA NEUROPATHOLOGICA COMMUNICATIONS - 2020
https://doi.org/10.1186/s40478-020-00980-z
Single-cell RNA-seq reveals cellular hierarchies and impaired developmental trajectories in pediatric ependymoma
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Gojo J, Englinger B, Jiang L, Hübner JM, Shaw ML, Hack OA, Madlener S, Kirchhofer D, Liu I, Pyrdol J, Hovestadt V, Mazzola E, Mathewson ND, Trissal M, Lötsch D, Dorfer C, Haberler C, Halfmann A, Mayr L, Peyrl A, Geyeregger R, Schwalm B, Mauermann M, Pajtler KW, Milde T, Shore ME, Geduldig JE, Pelton K, Czech T, Ashenberg O, Wucherpfennig KW, Rozenblatt-Rosen O, Alexandrescu S, Ligon KL, Pfister SM, Regev A, Slavc I, Berger W, Suvà ML, Kool M, Filbin MG.
CANCER CELL - 2020 https://doi.org/10.1016/j.ccell.2020.06.004 |
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The growing role of epigenetics in childhood cancers
Panditharatna, E., & Filbin, M. G.
CURRENT OPINION IN PEDIATRICS - 2020
https://doi.org/10.1097/MOP.0000000000000867
CURRENT OPINION IN PEDIATRICS - 2020
https://doi.org/10.1097/MOP.0000000000000867
Molecular and Clinicopathologic Features of Gliomas Harboring NTRK Fusions
Torre, M., Vasudevaraja, V., Serrano, J., DeLorenzo, M., Malinowski, S., Blandin, A. F., Pages, M., Ligon, A. H., Dong, F., Meredith, D. M., Nasrallah, M. P., Horbinski, C., Dahiya, S., Ligon, K. L., Santi, M., Ramkissoon, S. H., Filbin, M. G., Snuderl, M., & Alexandrescu, S.
ACTA NEUROPATHOLOGICA COMMUNICATIONS - 2020
https://doi.org/10.1186/s40478-020-00980-z
ACTA NEUROPATHOLOGICA COMMUNICATIONS - 2020
https://doi.org/10.1186/s40478-020-00980-z
Histone H3.3G34-Mutant Interneuron Progenitors Co-opt PDGFRA for Gliomagenesis
Chen, C. C. L., Deshmukh, S., Jessa, S., Hadjadj, D., Lisi, V., Andrade, A. F., Faury, D., Jawhar, W., Dali, R., Suzuki, H., Pathania, M., A, D., Dubois, F., Woodward, E., Hébert, S., Coutelier, M., Karamchandani, J., Albrecht, S., Brandner, S., De Jay, N., … Filbin, M. G., ... Jabado, N.
CELL - 2020
https://doi.org/10.1016/j.cell.2020.11.012
CELL - 2020
https://doi.org/10.1016/j.cell.2020.11.012
Trametinib for the treatment of recurrent/progressive pediatric low-grade glioma.
Manoharan N, Choi J, Chordas C, Zimmerman MA, Scully J, Clymer J, Filbin M, Ullrich NJ, Bandopadhayay P, Chi SN, Yeo KK.
J. NEURONCOL, 2020;149(2):253-262. https://doi.org/10.1007/s11060-020-03592-8
J. NEURONCOL, 2020;149(2):253-262. https://doi.org/10.1007/s11060-020-03592-8
Infiltrative gliomas of the thalamus in children: the role of surgery in the era of H3 K27M mutant midline gliomas.
Dorfer C, Czech T, Gojo J, Hosmann A, Peyrl A, Azizi AA, Kasprian G, Dieckmann K, Filbin MG, HaberlerG, Roessler K, Slavc I.
ACTA NEUROCHIR (WIEN), 2020; 163(7):2025-2035. https://doi.org/10.1007/s00701-020-04589-y
ACTA NEUROCHIR (WIEN), 2020; 163(7):2025-2035. https://doi.org/10.1007/s00701-020-04589-y
2019 Publications
Increasing value of autopsies in patients with brain tumors in the molecular era.
Ahrendsen JT, Filbin MG, Chi SN, Manley PE, Wright KD, Bandopadhayay P, Clymer JR, Yeo KK, Kieran MW, Jones R, Lidov HG, Ligon KL, Alexandrescu S.
J NEUROONCOL, 2019; 145:349–355. https://doi.org/10.1007/s11060-019-03302-z
J NEUROONCOL, 2019; 145:349–355. https://doi.org/10.1007/s11060-019-03302-z
Histone variant and cell context determine H3K27M reprogramming of the enhancer landscape and oncogenic state.
Nagaraja S, Quezada MA, Gillespie SM, Arzt M, Lennon JJ, Woo PJ, Hovestadt V, Kambhampati M, Filbin MG, Suva ML, Nazarian J, Monje M.
MOL CELL, 2019; S1097-2765(19):30685-9. https://doi.org/10.1016/j.molcel.2019.08.030
MOL CELL, 2019; S1097-2765(19):30685-9. https://doi.org/10.1016/j.molcel.2019.08.030
Rapid generation of somatic mouse mosaics with locus-specific, stably integrated transgenic elements.
Kim GB, Rincon Fernandez Pacheco D, Saxon D, Yang A, Sabet S, Dutra-Clarke M, Levy R, Watkins A, Park H, Abbasi Akhtar A, Linesch PW, Kobritz N, Chandra SS, Grausam K, Ayala-Sarmiento A, Molina J, Sedivakova K, Hoang K, Tsyporin J, Gareau DS, Filbin MG, Bannykh S, Santiskulvong C, Wang Y, Tang J, Suva ML, Chen B, Danielpour M, Breunig JJ.
CELL, 2019; 179(1):251-267.e24. https://doi.org/10.1016/j.cell.2019.08.013
CELL, 2019; 179(1):251-267.e24. https://doi.org/10.1016/j.cell.2019.08.013
Re-programing chromatin with a bifunctional LSD1/HDAC inhibitor induces therapeutic differentiation in DIPG.
Anastas JN, Zee BM, Kalin JH, Kim M, Guo R, Alexandrescu S, Blanco MA, Giera S, Gillespie SM, Das J, Wu M, Nocco S, Bonal DM, Nguyen Q-D, Suvà ML, Bernstein BE, Alani R, Golub TR, Cole PA, Filbin MG*, Shi Y*.
* contributed equally and co-corresponding
CANCER CELL, 2019; in press. https://doi.org/10.1016/j.ccell.2019.09.005
* contributed equally and co-corresponding
CANCER CELL, 2019; in press. https://doi.org/10.1016/j.ccell.2019.09.005
Resolving medulloblastoma cellular architecture by single-cell genomics.
Hovestadt V*, Smith KS*, Bihannic L*, Filbin MG*, Shaw ML, Baumgartner A, DeWitt JC, Groves A, Mayr L, Weisman HR, Richman AR, Shore ME, Goumnerova L, Rosencrance C, Carter RA, Phoenix TN, Hadley JL, Tong Y, Houston J, Ashmun RA, DeCuypere M, Sharma T, Flasch D, Silkov A, Ligon KL, Pomeroy SL, Rivera MN, Rozenblatt-Rosen O, Rusert JM, Wechsler-Reya RJ, Li XN, Peyrl A, Gojo J, Kirchhofer D, Lötsch D, Czech T, Dorfer C, Haberler C, Geyeregger R, Halfmann A, Gawad C, Easton J, Pfister SM, Regev A, Gajjar A, Orr BA, Slavc I, Robinson GW, Bernstein BE, Suvà ML, Northcott PA.
* contributed equally
NATURE, 2019; 572(7767):74-79. https://doi.org/10.1038/s41586-019-1434-6
* contributed equally
NATURE, 2019; 572(7767):74-79. https://doi.org/10.1038/s41586-019-1434-6
An integrative model of cellular states, plasticity, and genetics for glioblastoma.
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Neftel C*, Laffy J*, Filbin MG*, Hara T*, Shore ME, Rahme GJ, Richman AR, Silverbush D, Shaw ML, Hebert CM, Dewitt J, Gritsch S, Perez EM, Gonzalez Castro LN, Lan X, Druck N, Rodman C, Dionne D, Kaplan A, Bertalan MS, Small J, Pelton K, Becker S, Bonal D, Nguyen QD, Servis RL, Fung JM, Mylvaganam R, Mayr L, Gojo J, Haberler C, Geyeregger R, Czech T, Slavc I, Nahed BV, Curry WT, Carter BS, Wakimoto H, Brastianos PK, Batchelor TT, Stemmer-Rachamimov A, Martinez-Lage M, Frosch MP, Stamenkovic I, Riggi N, Rheinbay E, Monje M, Rozenblatt-Rosen O, Cahill DP, Patel AP, Hunter T, Verma IM, Ligon KL, Louis DN, Regev A, Bernstein BE, Tirosh I, Suvà ML.
* contributed equally CELL, 2019; 178(4):835-849.e21. https://doi.org/10.1016/j.cell.2019.06.024 |
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Developmental origins and emerging therapeutic opportunities for childhood cancer.
2013 - 2018 Publications
Non-inflammatory tumor microenvironment of diffuse intrinsic pontine glioma.
Lin GL, Nagaraja S, Filbin MG, Suva ML, Vogel H, Monje M
ACTA NEUROPATHOL COMMUN, 2018; 6:51. https://doi.org/10.1186/s40478-018-0553-x
ACTA NEUROPATHOL COMMUN, 2018; 6:51. https://doi.org/10.1186/s40478-018-0553-x
Developmental and oncogenic programs in H3K27M gliomas dissected by single-cell RNA-seq.
Filbin MG*, Tirosh I*, Hovestadt V*, Shaw ML, Escalante LE, Mathewson ND, Neftel C, Frank N, Pelton K, Hebert CM, Haberler C, Yizhak K, Gojo J, Egervari K, Mount C, Van Galen P, Bonal D, Nguyen QD, Beck A, Sinai C, Czech T, Dorfer C, Goumnerova L, Lavarino C, Carcaboso AM, Mora J, Mylvaganam R, Luo CC, Peyrl A, Popovic M, Azizi A, Batchelor TT, Frosch MP, Martinez-Lage M, Kieran MW, Bandopadhayay P, Beroukhim R, Fritsch G, Getz G, Rozenblatt-Rosen O, Wucherpfennig KW, Louis DN, Monje M, Slavc I, Ligon KL, Golub TR, Regev A, Bernstein B, Suva ML.
* contributed equally
SCIENCE, 2018; 360:331-335. https://doi.org/10.1126/science.aao4750
* contributed equally
SCIENCE, 2018; 360:331-335. https://doi.org/10.1126/science.aao4750
Gliomas in Children.
Filbin MG, Sturm D.
SEMINARS IN NEUROLOGY, 2018; 38:121-130. https://doi.org/10.1055/s-0038-1635106
SEMINARS IN NEUROLOGY, 2018; 38:121-130. https://doi.org/10.1055/s-0038-1635106
Molecular pathogenesis and therapeutic implications in pediatric high-grade gliomas.
Juratli TA, Qin N, Cahill DP, Filbin MG.
PHARMACOL THER, 2018; 182:70-79. https://doi.org/10.1016/j.pharmthera.2017.08.006
PHARMACOL THER, 2018; 182:70-79. https://doi.org/10.1016/j.pharmthera.2017.08.006
Decoupling genetic developmental and micro-environmental programs in IDH-mutant gliomas thorugh single-cell RNA-seq.
Venteicher AS, Tirosh I, Hebert C, Yizhak K, Neftel C, Filbin MG, Hovestadt V, Escalante LE, Shaw ML, Rodman C, Gillespie SM, Dionne D, Luo CC, Ravichadran H, Mylvaganam R, Mout C, Onozato ML, Nahed BV, Wakimoto H, Curry WT, Iafrate AJ, Rivera MN, Frosch MP, Golub TR, Brastianos PK, Getz G, Patel AP, Monje J, Cahill DP, Rozenblatt-Rosen O, Louis DN, Bernstein BE, Regev A, Suva ML.
SCIENCE, 2017; 355(6332). https://doi.org/10.1126/science.aai8478
SCIENCE, 2017; 355(6332). https://doi.org/10.1126/science.aai8478
Clinical targeted exome-based sequencing in combination with genome-wide copy number profiling: precision medicine analysis of 203 pediatric brain tumors.
Ramkissoon SH, Bandopadhayay P, Hwang J, Ramkissoon LA, Greenwald NF, Schumacher SE, O'Rourke R1, Pinches N, Ho P, Malkin H, Sinai C, Filbin M, Plant A, Bi WL, Chang MS, Yang E, Wright KD, Manley PE, Ducar M, Alexandrescu S, Lidov H, Delalle I, Goumnerova LC, Church AJ, Janeway KA, Harris MH, MacConaill LE, Folkerth RD, Lindeman NI, Stiles CD, Kieran MW, Ligon AH, Santagata S, Dubuc AM, Chi SN, Beroukhim R, Ligon KL.
NEURO ONCOL, 2017; 7:986-996. https://doi.org/10.1093/neuonc/now294
NEURO ONCOL, 2017; 7:986-996. https://doi.org/10.1093/neuonc/now294
Single cell RNA-seq supports a developmental hierarchy in IDH-mutant oligodendroglioma.
Tirosh I, Venteicher AS, Hebert C, Escalante LE, Patel AP, Yizhak K, Fisher JM, Rodman C, Mount C, Filbin MG, Neftel C, Desai N, Nyman J, Izar B, Luo CC, Francis JM, Patel AA, Onozato, Riggi N, Livak KJ, Gennert D, Satija R, Nahed BV, Curry WT, Martuza RL, Mylvaganam R, Iafrate AJ, Frosch MP, Golub T, Rivera MN, Getz G, Rozenblatt-Rosen O, Cahill D, Monje M, Bernstein BE, Louis DN, Regev A, Suva ML.
NATURE, 2016; 539(7628):309-313. https://doi.org/10.1038/nature20123
NATURE, 2016; 539(7628):309-313. https://doi.org/10.1038/nature20123
Glioma genomics and epigenomics: arriving at the start and knowing it for the first time.
Filbin MG, Suva ML.
ANNU REV PATHOL, 2016; 11:497-521. https://doi.org/10.1146/annurev-pathol-012615-044208
ANNU REV PATHOL, 2016; 11:497-521. https://doi.org/10.1146/annurev-pathol-012615-044208
Of Brains and Blood: Developmental Origins of Glioma Diversity?
How neuronal activity regulates glioma cell proliferation.
A brain tumor/organotypic slice co-culture system for studying tumor microenvironment and targeted drug therapies.
Chadwick, E. J., Yang, D. P., Filbin, M. G., Mazzola, E., Sun, Y., Behar, O., Pazyra-Murphy, M. F., Goumnerova, L., Ligon, K. L., Stiles, C. D., & Segal, R. A.
J VIS EXP, 2015; https://doi.org/10.3791/53304
J VIS EXP, 2015; https://doi.org/10.3791/53304
Coordinate activation of Shh and PI3K signaling in PTEN-deficient Glioblastoma: new therapeutic opportunities.
Filbin, M. G., Dabral, S. K., Pazyra-Murphy, M. F., Ramkissoon, S., Kung, A. L., Pak, E., Chung, J., Theisen, M. A., Sun, Y., Franchetti, Y., Sun, Y., Shulman, D. S., Redjal, N., Tabak, B., Beroukhim, R., Wang, Q., Zhao, J., Dorsch, M., Buonamici, S., Ligon, K. L., … Segal, R. A.
NATURE MEDICINE, 2013; https://doi.org/10.1038/nm.3328
NATURE MEDICINE, 2013; https://doi.org/10.1038/nm.3328