2023 Publications
A comprehensive genomic study of 390 H3F3A-mutant pediatric and adult diffuse high-grade gliomas, CNS WHO grade 4
Williams, E. A., Brastianos, P. K., Wakimoto, H., Zolal, A., Filbin, M. G., Cahill, D. P., Santagata, S., & Juratli, T. A.
ACTA NEUROPATHOLOGICA, 2023; https://doi.org/10.1007/s00401-023-02609-6
ACTA NEUROPATHOLOGICA, 2023; https://doi.org/10.1007/s00401-023-02609-6
Clinical efficacy of ONC201 in H3K27M-mutant diffuse midline gliomas is driven by disruption of integrated metabolic and epigenetic pathways
Venneti, S., Kawakibi, A. R., Ji, S., Waszak, S. M., Sweha, S. R., Mota, M., Pun, M., Deogharkar, A., Chung, C., Tarapore, R. S., Ramage, S., Chi, A., Wen, P. Y., Arrillaga-Romany, I., Batchelor, T. T., Butowski, N. A., Sumrall, A., Shonka, N., Harrison, R. A., de Groot, J., … Filbin, M. G., ... Koschmann, C.
CANCER DISCOVERY, 2023; https://doi.org/10.1158/2159-8290.CD-23-0131
CANCER DISCOVERY, 2023; https://doi.org/10.1158/2159-8290.CD-23-0131
Mapping pediatric brain tumors to their origins in the developing cerebellum
Okonechnikov, K., Joshi, P., Sepp, M., Leiss, K., Sarropoulos, I., Murat, F., Sill, M., Beck, P., Chan, K. C., Korshunov, A., Sahm, F., Deng, M. Y., Sturm, D., DeSisto, J., Donson, A. M., Foreman, N. K., Green, A. L., Robinson, G., Orr, B. A., Gao, Q., … Filbin, M. G., ... Pfister, S. M.
NEURO-ONCOLOGY, 2022; https://doi.org/10.1093/neuonc/noad124
NEURO-ONCOLOGY, 2022; https://doi.org/10.1093/neuonc/noad124
Why haven't we solved intracranial pediatric ependymoma? Current questions and barriers to treatment advances
Hwang, E. I., Hanson, D., Filbin, M. G., & Mack, S. C.
NEUOPLASIA, 2023; https://doi.org/10.1016/j.neo.2023.100895
NEUOPLASIA, 2023; https://doi.org/10.1016/j.neo.2023.100895
Common molecular features of H3K27M DMGs and PFA ependymomas map to hindbrain developmental pathways
Pun, M., Pratt, D., Nano, P. R., Joshi, P. K., Jiang, L., Englinger, B., Rao, A., Cieslik, M., Chinnaiyan, A. M., Aldape, K., Pfister, S., Filbin, M. G., Bhaduri, A., & Venneti, S.
ACTA NEUROPATHOLOGICA COMMUNICATIONS, 2023; https://doi.org/10.1186/s40478-023-01514-z
ACTA NEUROPATHOLOGICA COMMUNICATIONS, 2023; https://doi.org/10.1186/s40478-023-01514-z
2022 Publications
The landscape of tumor cell states and spatial organization in H3-K27M mutant diffuse midline glioma across age and location
Liu, I., Jiang, L., Samuelsson, E. R., Marco Salas, S., Beck, A., Hack, O. A., Jeong, D., Shaw, M. L., Englinger, B., LaBelle, J., Mire, H. M., Madlener, S., Mayr, L., Quezada, M. A., Trissal, M., Panditharatna, E., Ernst, K. J., Vogelzang, J., Gatesman, T. A., Halbert, M. E., … Filbin, M. G.
NATURE GENETICS, 2022; 10.1038/s41588-022-01236-3
NATURE GENETICS, 2022; 10.1038/s41588-022-01236-3
Characterizing the biology of primary brain tumors and their microenvironment via single-cell profiling methods
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Gonzalez Castro, L. N., Liu, I., & Filbin, M.
NEURO-ONCOLOGY, 2022; https://doi.org/10.1093/neuonc/noac211 |
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BAF complex maintains glioma stem cells in pediatric H3K27M-glioma
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Panditharatna, E., G Marques, J., Wang, T., Trissal, M. C., Liu, I., Jiang, L., Beck, A., Groves, A., Dharia, N. V., Li, D., Hoffman, S. E., Kugener, G., Shaw, M. L., Mire, H. M., Hack, O. A., Dempster, J. M., Lareau, C., Dai, L., Sigua, L. H., Quezada, M. A., … Filbin, M. G.
CANCER DISCOVERY, 2022; https://doi.org/10.1158/2159-8290.CD-21-1491 |
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VRK1 as a synthetic lethal target in VRK2 promoter-methylated cancers of the nervous system
So, J., Mabe, N. W., Englinger, B., Chow, K. H., Moyer, S. M., Yerrum, S., Trissal, M. C., Marques, J. G., Kwon, J. J., Shim, B., Pal, S., Panditharatna, E., Quinn, T., Schaefer, D. A., Jeong, D., Mayhew, D. L., Hwang, J., Beroukhim, R., Ligon, K. L., Stegmaier, K., … Filbin G. M., Hahn, W. C.
JCI INSIGHT, 2022; https://doi.org/10.1172/jci.insight.158755
JCI INSIGHT, 2022; https://doi.org/10.1172/jci.insight.158755
Immunotherapy approaches for the treatment of diffuse midline gliomas
Bernstock, J. D., Hoffman, S. E., Kappel, A. D., Valdes, P. A., Essayed, W., Klinger, N. V., Kang, K. D., Totsch, S. K., Olsen, H. E., Schlappi, C. W., Filipski, K., Gessler, F. A., Baird, L., Filbin, M. G., Hashizume, R., Becher, O. J., & Friedman, G. K.
ONCOIMMUNOLOGY, 2022; https://doi.org/10.1080/2162402X.2022.2124058
ONCOIMMUNOLOGY, 2022; https://doi.org/10.1080/2162402X.2022.2124058
A druggable addiction to de novo pyrimidine biosynthesis in diffuse midline glioma
Sharmistha Pal, Jakub P. Kaplan, Huy Nguyen, Sylwia A. Stopka, Milan R. Savani, Michael S. Regan, Quang-De Nguyen, Kristen L. Jones, Lisa A. Moreau, Jingyu Peng, Marina G. Dipiazza, Andrew J. Perciaccante, Xiaoting Zhu, Bradley R. Hunsel, Kevin X. Liu, Sanda Alexandrescu, Rachid Drissi, Mariella G. Filbin, Samuel K. McBrayer, Nathalie Y.R. Agar, Dipanjan Chowdhury, Daphne A. Haas-Kogan
CANCER CELL, 2022; https://doi.org/10.1016/j.ccell.2022.07.012
CANCER CELL, 2022; https://doi.org/10.1016/j.ccell.2022.07.012
An affinity for brainstem microglia in pediatric high-grade gliomas of brainstem origin
Zats, L. P., Ahmad, L., Casden, N., Lee, M. J., Belzer, V., Adato, O., Bar Cohen, S., Ko, S. B., Filbin, M. G., Unger, R., Lauffenburger, D. A., Segal, R. A., & Behar, O.
NEURO-ONCOLOGY ADVANCES, 2022; https://doi.org/10.1093/noajnl/vdac117
NEURO-ONCOLOGY ADVANCES, 2022; https://doi.org/10.1093/noajnl/vdac117
Single-cell epigenetic analysis reveals principles of chromatin states in H3.3-K27M gliomas
Harpaz, N., Mittelman, T., Beresh, O., Griess, O., Furth, N., Salame, T. M., Oren, R., Fellus-Alyagor, L., Harmelin, A., Alexandrescu, S., Marques, J. G., Filbin, M. G., Ron, G., & Shema, E.
MOLECULAR CELL, 2022; https://doi.org/10.1016/j.molcel.2022.05.023
MOLECULAR CELL, 2022; https://doi.org/10.1016/j.molcel.2022.05.023
Activation of Hedgehog signaling by the oncogenic RELA fusion reveals a primary cilia-dependent vulnerability in Supratentorial Ependymoma
de Almeida Magalhães, T., Alencastro Veiga Cruzeiro, G., Ribeiro de Sousa, G., Englinger, B., Fernando Peinado Nagano, L., Ancliffe, M., Rodrigues da Silva, K., Jiang, L., Gojo, J., Cherry Liu, Y., Carline, B., Kuchibhotla, M., Pinto Saggioro, F., Kazue Nagahashi Marie, S., Mieko Oba-Shinjo, S., Andres Yunes, J., Gomes de Paula Queiroz, R., Alberto Scrideli, C., Endersby, R., Filbin, M. G., … Valera, E. T.
NEURO-ONCOLOGY, 2022; https://doi.org/10.1093/neuonc/noac147
NEURO-ONCOLOGY, 2022; https://doi.org/10.1093/neuonc/noac147
Therapeutic targeting of prenatal pontine ID1 signaling in diffuse midline glioma
Messinger, D., Harris, M. K., Cummings, J. R., Thomas, C., Yang, T., Sweha, S. R., Woo, R., Siddaway, R., Burkert, M., Stallard, S., Qin, T., Mullan, B., Siada, R., Ravindran, R., Niculcea, M., Dowling, A. R., Bradin, J., Ginn, K. F., Gener, M. A. H., Dorris, K., … Filbin, M. G., ... Yadav, V. N.
NEURO-ONCOLOGY, 2022; https://doi.org/10.1093/neuonc/noac141
NEURO-ONCOLOGY, 2022; https://doi.org/10.1093/neuonc/noac141
Bromodomain and Extra-Terminal Protein Inhibitors: Biologic Insights and Therapeutic Potential in Pediatric Brain Tumors.
Groves, A., Clymer, J., & Filbin, M. G.
PHARMACEUTICALS (BASEL, SWITZERLAND), 2022; https://doi.org/10.3390/ph15060665
PHARMACEUTICALS (BASEL, SWITZERLAND), 2022; https://doi.org/10.3390/ph15060665
GD2-CAR T cell therapy for H3K27M-mutated diffuse midline gliomas
Majzner, R. G., Ramakrishna, S., Yeom, K. W., Patel, S., Chinnasamy, H., Schultz, L. M., Richards, R. M., Jiang, L., Barsan, V., Mancusi, R., Geraghty, A. C., Good, Z., Mochizuki, A. Y., Gillespie, S. M., Toland, A. M. S., Mahdi, J., Reschke, A., Nie, E. H., Chau, I. J., Rotiroti, M. C., … Filbin, M. G., ... Monje, M.
NATURE, 2022; https://doi.org/10.1038/s41586-022-04489-4
NATURE, 2022; https://doi.org/10.1038/s41586-022-04489-4
Imipridones affect tumor bioenergetics and promote cell lineage differentiation in diffuse midline gliomas
Przystal, J. M., Cianciolo Cosentino, C., Yadavilli, S., Zhang, J., Laternser, S., Bonner, E. R., Prasad, R., Dawood, A. A., Lobeto, N., Chin Chong, W., Biery, M. C., Myers, C., Olson, J. M., Panditharatna, E., Kritzer, B., Mourabit, S., Vitanza, N. A., Filbin, M. G., de Iuliis, G. N., Dun, M. D., … Nazarian, J.
NEURO-ONCOLOGY, 2022; https://doi.org/10.1093/neuonc/noac041
NEURO-ONCOLOGY, 2022; https://doi.org/10.1093/neuonc/noac041
2021 Publications
The imitation game: How glioblastoma outmaneuvers immune attack.
Understanding the epigenetic landscape and cellular architecture of childhood brain tumors.
Cruzeiro GAV, Rota C, Hack OA, Segal R, Filbin MG.
NEUROCHEM. INT., 2021; 144: 104940. https://doi.org/10.1016/j.neuint.2020.104940.
NEUROCHEM. INT., 2021; 144: 104940. https://doi.org/10.1016/j.neuint.2020.104940.
Outcomes after first relapse of childhood intracranial ependymoma.
Tsai JW, Manoharan N, Alexandrescu S, Zimmerman MA, Scully J, Chordas C, Clymer J, Wright KD, Filbin M, Ullrich NJ, Marcus KJ, Haas-Kogan D, Chi SN, Bandopadhayay P, Yeo KK.
PEDIATR BLOOD CANCER, 2021; 68(8):e28930. https://doi.org/10.1002/pbc.28930
PEDIATR BLOOD CANCER, 2021; 68(8):e28930. https://doi.org/10.1002/pbc.28930
Targeting fibroblast growth factor receptors to combat aggressive ependymoma.
Lötsch D, Kirchhofer D, Englinger B, Jiang L, Okonechnikov K, Senfter D, Laemmerer A, Gabler L, Pirker C, Donson AM, Bannauer P, Korbel P, Jaunecker CN, Hübner JM, Mayr L, Madlener S, Schmook MT, Ricken G, Maaß K, Grusch M, Holzmann K, Grasl-Kraupp B, Spiegl-Kreinecker S, Hsu J, Dorfer C, Rössler K, Azizi AA, Foreman NK, Peyrl A, Haberler C, Czech T, Slavc I, Filbin MG, Pajtler KW, Kool M, Berger W, Gojo J.
ACTA NEUROPATHOL, 2021; 142, 339–360. https://doi.org/10.1007/s00401-021-02327-x
ACTA NEUROPATHOL, 2021; 142, 339–360. https://doi.org/10.1007/s00401-021-02327-x
Targeting integrated epigenetic and metabolic pathways in lethal childhood PFA ependymomas.
Panwalkar P, Tamrazi B, Dang D, Chung C, Sweha S, Natarajan SK, Pun M, Bayliss J, Ogrodzinski MP, Pratt D, Mullan B, Hawes D, Yang F, Lu C, Sabari BR, Achreja A, Heon J, Animasahun O, Cieslik M, Dunham C, Yip S, Hukin J, Phillips JJ, Bornhorst M, Griesinger AM, Donson AM, Foreman NK, Garton HJL, Heth J, Muraszko K, Nazarian J, Koschmann C, Jiang L, Filbin MG, Nagrath D, Kool M, Korshunov A, Pfister SM, Gilbertson RJ, Allis CD, Chinnaiyan AM, Lunt SY, Blüml S, Judkins AR, Venneti S.
SCI TRANSL MED, 2021; 13(614). https://doi.org/10.1126/scitranslmed.abc0497
SCI TRANSL MED, 2021; 13(614). https://doi.org/10.1126/scitranslmed.abc0497
2020 Publications
Into Thin Air: Hypoxia drives metabolic and epigenomic deregulation of lethal pediatric ependymoma.
Englinger B, Hack OA, Filbin MG.
DEV. CELL, 2020; 54(2):134-136. https://doi.org/10.1016/j.devcel.2020.06.020
DEV. CELL, 2020; 54(2):134-136. https://doi.org/10.1016/j.devcel.2020.06.020
Molecular and clinicopathologic features of gliomas harboring NTRK fusions.
Torre M, Vasudevaraja V, Serrano J, DeLorenzo M, Malinowski S, Blandin A, Pages M, Ligon AH, Dong F, Meredith DM, Nasrallah MP, Horbinski C, Dahiya S, Ligon KL, Santi M, Ramkissoon SH, Filbin MG, Snuderl M, Alexandrescu S.
ACTA NEUROPATHOL COMMUN, 2020; 8(107). https://doi.org/10.1186/s40478-020-00980-z
ACTA NEUROPATHOL COMMUN, 2020; 8(107). https://doi.org/10.1186/s40478-020-00980-z
Single-cell RNA-seq reveals cellular hierarchies and impaired developmental trajectories in pediatric ependymoma.
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Gojo J, Englinger B, Jiang L, Hübner JM, Shaw ML, Hack OA, Madlener S, Kirchhofer D, Liu I, Pyrdol J, Hovestadt V, Mazzola E, Mathewson ND, Trissal M, Lötsch D, Dorfer C, Haberler C, Halfmann A, Mayr L, Peyrl A, Geyeregger R, Schwalm B, Mauermann M, Pajtler KW, Milde T, Shore ME, Geduldig JE, Pelton K, Czech T, Ashenberg O, Wucherpfennig KW, Rozenblatt-Rosen O, Alexandrescu S, Ligon KL, Pfister SM, Regev A, Slavc I, Berger W, Suvà ML, Kool M, Filbin MG.
CANCER CELL, 2020; 38(1):44-59.e9. https://doi.org/10.1016/j.ccell.2020.06.004 |
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The growing role of epigenetics in childhood cancers.
Panditharatna E, Filbin MG.
CURR OPIN PEDIATR, 2020; 32(1):67-75. https://doi.org/10.1097/MOP.0000000000000867
CURR OPIN PEDIATR, 2020; 32(1):67-75. https://doi.org/10.1097/MOP.0000000000000867
Molecular and Clinicopathologic Features of Gliomas Harboring NTRK Fusions.
Torre M, Vasudevaraja V, Serrano J, DeLorenzo M, Malinowski S, Blandin AF, Pages M, Ligon AH, Dong F, Meredith DV, Nasrallah MP, Horbinski C, Dahiya S, Ligon KL, Santi M, Ramkissoon S, Filbin MG*, Snuderl M*, Alexandrescu S*.
ACTA NEUROPATHOL. COMMUN, 2020; 8(1):107. https://doi.org/10.1186/s40478-020-00980-z
ACTA NEUROPATHOL. COMMUN, 2020; 8(1):107. https://doi.org/10.1186/s40478-020-00980-z
Histone H3.3G34-Mutant Interneuron Progenitors Co-opt PDGFRA for Gliomagenesis.
Chen CCL, Deshmukh S, Jessa S, Hadjadj D, Lisi V, Andrade AF, Faury D, Jawhar W, Dali R, Suzuki H, Pathania M, A D, Dubois F, Woodward E, Hébert S, Coutelier M, Karamchandani J, Albrecht S, Brandner S, De Jay N, Gayden T, Bajic A, Harutyunyan AS, Marchione DM, Mikael LG, Juretic N, Zeinieh M, Russo C, Maestro N, Bassenden AV, Hauser P, Virga J, Bognar L, Klekner A, Zapotocky M, Vicha A, Krskova L, Vanova K, Zamecnik J, Sumerauer D, Ekert PG, Ziegler DS, Ellezam B, Filbin MG, Blanchette M, Hansford JR, Khuong-Quang DA, Berghuis AM, Weil AG, Garcia BA, Garzia L, Mack SC, Beroukhim R, Ligon KL, Taylor MD, Bandopadhayay P, Kramm C, Pfister SM, Korshunov A, Sturm D, Jones DTW, Salomoni P, Kleinman CL, Jabado N.
CELL, 2020;183(6):1617-1633. https://doi.org/10.1016/j.cell.2020.11.012
CELL, 2020;183(6):1617-1633. https://doi.org/10.1016/j.cell.2020.11.012
Trametinib for the treatment of recurrent/progressive pediatric low-grade glioma.
Manoharan N, Choi J, Chordas C, Zimmerman MA, Scully J, Clymer J, Filbin M, Ullrich NJ, Bandopadhayay P, Chi SN, Yeo KK.
J. NEURONCOL, 2020;149(2):253-262. https://doi.org/10.1007/s11060-020-03592-8
J. NEURONCOL, 2020;149(2):253-262. https://doi.org/10.1007/s11060-020-03592-8
Infiltrative gliomas of the thalamus in children: the role of surgery in the era of H3 K27M mutant midline gliomas.
Dorfer C, Czech T, Gojo J, Hosmann A, Peyrl A, Azizi AA, Kasprian G, Dieckmann K, Filbin MG, HaberlerG, Roessler K, Slavc I.
ACTA NEUROCHIR (WIEN), 2020; 163(7):2025-2035. https://doi.org/10.1007/s00701-020-04589-y
ACTA NEUROCHIR (WIEN), 2020; 163(7):2025-2035. https://doi.org/10.1007/s00701-020-04589-y
2019 Publications
Increasing value of autopsies in patients with brain tumors in the molecular era.
Ahrendsen JT, Filbin MG, Chi SN, Manley PE, Wright KD, Bandopadhayay P, Clymer JR, Yeo KK, Kieran MW, Jones R, Lidov HG, Ligon KL, Alexandrescu S.
J NEUROONCOL, 2019; 145:349–355. https://doi.org/10.1007/s11060-019-03302-z
J NEUROONCOL, 2019; 145:349–355. https://doi.org/10.1007/s11060-019-03302-z
Histone variant and cell context determine H3K27M reprogramming of the enhancer landscape and oncogenic state.
Nagaraja S, Quezada MA, Gillespie SM, Arzt M, Lennon JJ, Woo PJ, Hovestadt V, Kambhampati M, Filbin MG, Suva ML, Nazarian J, Monje M.
MOL CELL, 2019; S1097-2765(19):30685-9. https://doi.org/10.1016/j.molcel.2019.08.030
MOL CELL, 2019; S1097-2765(19):30685-9. https://doi.org/10.1016/j.molcel.2019.08.030
Rapid generation of somatic mouse mosaics with locus-specific, stably integrated transgenic elements.
Kim GB, Rincon Fernandez Pacheco D, Saxon D, Yang A, Sabet S, Dutra-Clarke M, Levy R, Watkins A, Park H, Abbasi Akhtar A, Linesch PW, Kobritz N, Chandra SS, Grausam K, Ayala-Sarmiento A, Molina J, Sedivakova K, Hoang K, Tsyporin J, Gareau DS, Filbin MG, Bannykh S, Santiskulvong C, Wang Y, Tang J, Suva ML, Chen B, Danielpour M, Breunig JJ.
CELL, 2019; 179(1):251-267.e24. https://doi.org/10.1016/j.cell.2019.08.013
CELL, 2019; 179(1):251-267.e24. https://doi.org/10.1016/j.cell.2019.08.013
Re-programing chromatin with a bifunctional LSD1/HDAC inhibitor induces therapeutic differentiation in DIPG.
Anastas JN, Zee BM, Kalin JH, Kim M, Guo R, Alexandrescu S, Blanco MA, Giera S, Gillespie SM, Das J, Wu M, Nocco S, Bonal DM, Nguyen Q-D, Suvà ML, Bernstein BE, Alani R, Golub TR, Cole PA, Filbin MG*, Shi Y*.
* contributed equally and co-corresponding
CANCER CELL, 2019; in press. https://doi.org/10.1016/j.ccell.2019.09.005
* contributed equally and co-corresponding
CANCER CELL, 2019; in press. https://doi.org/10.1016/j.ccell.2019.09.005
Resolving medulloblastoma cellular architecture by single-cell genomics.
Hovestadt V*, Smith KS*, Bihannic L*, Filbin MG*, Shaw ML, Baumgartner A, DeWitt JC, Groves A, Mayr L, Weisman HR, Richman AR, Shore ME, Goumnerova L, Rosencrance C, Carter RA, Phoenix TN, Hadley JL, Tong Y, Houston J, Ashmun RA, DeCuypere M, Sharma T, Flasch D, Silkov A, Ligon KL, Pomeroy SL, Rivera MN, Rozenblatt-Rosen O, Rusert JM, Wechsler-Reya RJ, Li XN, Peyrl A, Gojo J, Kirchhofer D, Lötsch D, Czech T, Dorfer C, Haberler C, Geyeregger R, Halfmann A, Gawad C, Easton J, Pfister SM, Regev A, Gajjar A, Orr BA, Slavc I, Robinson GW, Bernstein BE, Suvà ML, Northcott PA.
* contributed equally
NATURE, 2019; 572(7767):74-79. https://doi.org/10.1038/s41586-019-1434-6
* contributed equally
NATURE, 2019; 572(7767):74-79. https://doi.org/10.1038/s41586-019-1434-6
An integrative model of cellular states, plasticity, and genetics for glioblastoma.
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Neftel C*, Laffy J*, Filbin MG*, Hara T*, Shore ME, Rahme GJ, Richman AR, Silverbush D, Shaw ML, Hebert CM, Dewitt J, Gritsch S, Perez EM, Gonzalez Castro LN, Lan X, Druck N, Rodman C, Dionne D, Kaplan A, Bertalan MS, Small J, Pelton K, Becker S, Bonal D, Nguyen QD, Servis RL, Fung JM, Mylvaganam R, Mayr L, Gojo J, Haberler C, Geyeregger R, Czech T, Slavc I, Nahed BV, Curry WT, Carter BS, Wakimoto H, Brastianos PK, Batchelor TT, Stemmer-Rachamimov A, Martinez-Lage M, Frosch MP, Stamenkovic I, Riggi N, Rheinbay E, Monje M, Rozenblatt-Rosen O, Cahill DP, Patel AP, Hunter T, Verma IM, Ligon KL, Louis DN, Regev A, Bernstein BE, Tirosh I, Suvà ML.
* contributed equally CELL, 2019; 178(4):835-849.e21. https://doi.org/10.1016/j.cell.2019.06.024 |
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Developmental origins and emerging therapeutic opportunities for childhood cancer.
2018 & Older Publications
Non-inflammatory tumor microenvironment of diffuse intrinsic pontine glioma.
Lin GL, Nagaraja S, Filbin MG, Suva ML, Vogel H, Monje M
ACTA NEUROPATHOL COMMUN, 2018; 6:51. https://doi.org/10.1186/s40478-018-0553-x
ACTA NEUROPATHOL COMMUN, 2018; 6:51. https://doi.org/10.1186/s40478-018-0553-x
Developmental and oncogenic programs in H3K27M gliomas dissected by single-cell RNA-seq.
Filbin MG*, Tirosh I*, Hovestadt V*, Shaw ML, Escalante LE, Mathewson ND, Neftel C, Frank N, Pelton K, Hebert CM, Haberler C, Yizhak K, Gojo J, Egervari K, Mount C, Van Galen P, Bonal D, Nguyen QD, Beck A, Sinai C, Czech T, Dorfer C, Goumnerova L, Lavarino C, Carcaboso AM, Mora J, Mylvaganam R, Luo CC, Peyrl A, Popovic M, Azizi A, Batchelor TT, Frosch MP, Martinez-Lage M, Kieran MW, Bandopadhayay P, Beroukhim R, Fritsch G, Getz G, Rozenblatt-Rosen O, Wucherpfennig KW, Louis DN, Monje M, Slavc I, Ligon KL, Golub TR, Regev A, Bernstein B, Suva ML.
* contributed equally
SCIENCE, 2018; 360:331-335. https://doi.org/10.1126/science.aao4750
* contributed equally
SCIENCE, 2018; 360:331-335. https://doi.org/10.1126/science.aao4750
Gliomas in Children.
Filbin MG, Sturm D.
SEMINARS IN NEUROLOGY, 2018; 38:121-130. https://doi.org/10.1055/s-0038-1635106
SEMINARS IN NEUROLOGY, 2018; 38:121-130. https://doi.org/10.1055/s-0038-1635106
Molecular pathogenesis and therapeutic implications in pediatric high-grade gliomas.
Juratli TA, Qin N, Cahill DP, Filbin MG.
PHARMACOL THER, 2018; 182:70-79. https://doi.org/10.1016/j.pharmthera.2017.08.006
PHARMACOL THER, 2018; 182:70-79. https://doi.org/10.1016/j.pharmthera.2017.08.006
Decoupling genetic developmental and micro-environmental programs in IDH-mutant gliomas thorugh single-cell RNA-seq.
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